Messenger RNA for an antigen-specific binding molecule from an antigen-specific T-cell hybrid.

Messenger RNA for an antigen-specific binding molecule from an antigen-specific T-cell hybrid.

The T-cell hybridoma 51H7D specifically binds the hapten azobenzenearsonate (ABA). An antiserum (anti-PCIF) specific for antigenic determinants shared by antigen-binding molecules of T cells (TABM) was used to precipitate polyribosomes containing mRNA for TABM from this T-cell hybridoma. The resultant mRNA was translated in vitro. The translated product (TrP51H7D) bound specifically ABA and was...

Evidence for an immunoglobulin-dependent antigen-specific helper T cell.

Evidence from various systems suggests that thymus-derived lymphocytes can affect the quality of antibody responses by recognizing various portions of the immunoglobulin receptor of bone-marrow-derived thymus-independent lymphocytes. A model for this process is proposed involving two antigen-specific mature T helper cells, one of which also is specific for immunoglobulin determinants. These two...

Age Specific Reference Levels of Serum Prostate-Specific Antigen, Prostate Volume and Prostate Specific Antigen Density in Healthy Iranian Men

Background: It is relevant to highlight that there is not a precise and perfect report on either 95 percentile value (upper limit of normal range) or on appropriate reference intervals for serum PSA in Iranian population. Objective: To determine age-specific reference ranges for serum prostate-specific antigen (PSA) concentration and PSA density (PSAD) and prostate volumes in a population of he...

Antigen-Specific T Cells Maintain an Effector

Antigen-specific T cell therapies for cancer.

Adoptively transferred antigen-specific T cells that recognize tumor antigens through their native receptors have many potential benefits as treatment for virus-associated diseases and malignancies, due to their ability to selectively recognize tumor antigens, expand and persist to provide long-term protection. Infusions of T cells targeting Epstein-Barr virus (EBV) antigens have shown encourag...